If Trump selects Rubio as Secretary of State, DeSantis would gain the power to appoint a temporary Senate replacement.

Ron DeSantis. Assuming Rubio is confirmed by his colleagues ... firm of Holland & Knight where she practiced commercial litigation, and later joined the United States Attorney’s Office prosecuting drug, firearm, and fraud offenses. In 2006, at age ...

Rubio, in his third term in the U.S. Senate, has been steeped in intelligence matters and promises a pro-active posture regarding threats from China, Russia, Iran, and their allies. He was short listed for Vice President, but ultimately the hurdle of having two members of the ticket from the same state seemed to be a deal breaker for Trump.